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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AURKA
All Species:
38.48
Human Site:
S186
Identified Species:
56.44
UniProt:
O14965
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O14965
NP_003591.2
403
45809
S186
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Chimpanzee
Pan troglodytes
XP_525364
403
45791
S186
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Rhesus Macaque
Macaca mulatta
XP_001098364
471
52859
A258
R
R
E
I
E
I
Q
A
H
L
Q
H
P
N
I
Dog
Lupus familis
XP_853397
405
45606
S187
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Cat
Felis silvestris
Mouse
Mus musculus
P97477
395
44754
S177
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Rat
Rattus norvegicus
P59241
397
44856
S179
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521399
303
34973
L93
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
Chicken
Gallus gallus
XP_425725
409
46456
V188
A
Q
L
E
D
A
G
V
E
H
Q
L
R
R
E
Frog
Xenopus laevis
Q91819
408
46443
S193
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Zebra Danio
Brachydanio rerio
Q6NW76
320
36928
H110
E
I
Q
S
H
L
R
H
P
N
I
L
R
F
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKN7
329
38282
T118
P
H
I
L
R
L
L
T
W
F
H
D
E
S
R
Honey Bee
Apis mellifera
XP_395732
327
37711
T117
R
R
E
I
E
I
Q
T
H
L
R
H
P
N
I
Nematode Worm
Caenorhab. elegans
O01427
305
34731
T95
P
N
I
I
K
L
Y
T
Y
F
W
D
A
K
K
Sea Urchin
Strong. purpuratus
XP_001181990
278
32048
I68
S
H
L
R
H
P
N
I
L
R
L
F
G
Y
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q683C9
282
32738
S72
R
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
Baker's Yeast
Sacchar. cerevisiae
P38991
367
42927
T157
R
R
E
V
E
I
Q
T
S
L
N
H
P
N
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
100
47.7
89.8
N.A.
82.6
83.6
N.A.
65.5
73.1
65.9
53.3
N.A.
38.4
53
46.6
50.6
Protein Similarity:
100
100
62.2
93
N.A.
86.8
87.3
N.A.
70.2
82.8
77.2
65.7
N.A.
57.8
67
56.3
60
P-Site Identity:
100
100
80
100
N.A.
100
100
N.A.
6.6
0
100
0
N.A.
0
86.6
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
20
100
20
N.A.
26.6
100
33.3
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
46.4
38.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.3
57.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
100
73.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
100
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
7
0
7
0
0
0
0
7
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
7
0
0
0
0
0
0
13
0
0
0
% D
% Glu:
7
0
63
7
63
0
0
0
7
0
0
0
7
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
0
7
0
13
7
% F
% Gly:
0
0
0
0
0
0
7
0
0
0
0
7
7
0
0
% G
% His:
7
13
0
7
13
0
0
7
57
7
7
63
0
0
7
% H
% Ile:
0
7
13
19
0
63
7
7
0
0
7
0
0
0
57
% I
% Lys:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
7
% K
% Leu:
0
7
13
7
0
19
7
7
7
69
7
13
0
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
7
7
0
0
7
7
0
0
63
0
% N
% Pro:
13
0
0
0
7
7
0
0
7
0
0
0
63
0
0
% P
% Gln:
0
7
7
0
0
0
63
0
0
0
13
0
0
0
0
% Q
% Arg:
63
63
7
7
7
0
7
0
7
7
50
0
13
7
7
% R
% Ser:
7
0
0
7
0
0
0
44
7
0
0
0
0
7
0
% S
% Thr:
0
0
0
0
0
0
0
25
0
0
0
0
0
0
0
% T
% Val:
0
0
0
50
0
0
0
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
7
0
7
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _